Which Image Comics female character has had the most significant impact on cross-media adaptations to date?

While Image Comics has had fewer direct cross-media adaptations compared to other major publishers, Atom Eve from *Invincible* has arguably had the most significant recent impact. She is a central character in the critically acclaimed *Invincible* animated series on Amazon Prime Video, which has brought her complex character, unique powers, and compelling story to a much wider global audience, solidifying her status as a major Image Comics female icon outside of print. Witchblade also had a notable live-action TV series in the early 2000s.