Can corrupted AutoCAD profiles or settings cause this fatal error, and how can they be reset to default?

Yes, corrupted user profiles or settings can indeed lead to such errors, especially if they contain invalid paths, incorrect preferences, or references to non-existent resources. To reset them, use the 'Reset Settings to Default' utility typically found in the AutoCAD program group within the Windows Start Menu. This tool safely restores AutoCAD to its factory default settings without requiring a full reinstallation.