What role does DNA polymerase proofreading play in error correction?

By: USER8912
29 Agustus 2025 Support 5 minutes
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Grade: Education Subject: Support
What role does DNA polymerase proofreading play in error correction?
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DNA polymerase proofreading is the first line of defense against errors during DNA replication. Most DNA polymerases possess a 3' to 5' exonuclease activity, which allows them to backtrack and remove a newly incorporated nucleotide if it is mismatched. This intrinsic proofreading capability significantly reduces the error rate from approximately 1 in 10^5 to 1 in 10^7.
Answered on 29 Agustus 2025

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