Which DC supervillains have made the most impactful and memorable transitions from comics to live-action film and television?

Many DC supervillains have achieved significant impact in live-action adaptations. The Joker stands out with multiple iconic portrayals, including Jack Nicholson's in 'Batman' (1989), Heath Ledger's Oscar-winning performance in 'The Dark Knight,' and Joaquin Phoenix's 'Joker,' which earned him an Oscar. Lex Luthor has been memorably played by actors like Gene Hackman, Kevin Spacey, and Jesse Eisenberg. Harley Quinn, portrayed by Margot Robbie, became a breakout character in 'Suicide Squad' and 'Birds of Prey.' Other impactful adaptations include Bane (Tom Hardy in 'The Dark Knight Rises'), Darkseid (Ray Porter in 'Zack Snyder's Justice League'), and the Reverse-Flash (Tom Cavanagh in 'The Flash' TV series), who became a long-running, compelling antagonist.